Moderna/Pfizer mRNA Shots Trigger Enzyme Surge, Spike Protein Output

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A bombshell new study published last month in Nature confirms what vaccine manufacturers never disclosed: Both Moderna and Pfizer’s COVID-19 mRNA injections induce the body to produce an enzyme that rewrites the vaccine’s genetic message—prolonging spike protein production inside human cells.

Health authorities told us the spike protein only stays in the body “up to a few weeks,” but this website has reported on studies showing COVID shots force the body to produce spike protein for 187 days, 245 days, and even 709 days.

Moderna’s own scientists have admitted their mRNA vaccines pose “unacceptable toxicity” risks that present “challenges,” even going so far as to publish a paper in Nature Reviews Drug Discovery in January 2024 outlining strategies to “reduce the risks of mRNA drug and vaccine toxicity.”

The new Polish study, titled “Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines” (Krawczyk et al., 2025), reveals that after the mRNA vaccines are injected, immune cells called macrophages respond by producing a non-canonical poly(A) polymerase enzyme called TENT5A, meaning your body makes an enzyme it doesn’t usually produce—because the vaccine tells it to.

You can download the study.

TENT5A’s role is to extend the poly(A) tail of the mRNA, meaning it adds a long string of A’s (adenine nucleotides) to the end of the vaccine’s genetic code, making it more stable and longer-lived inside the cell.

This makes the mRNA survive longer than it naturally would and continue producing spike protein over an extended period.

“In vivo, TENT5A is expressed in immune cells that take up mRNA vaccine,” write the authors, adding that its absence “reduces specific immunoglobulin production.”

But TENT5A doesn’t just help the immune system.

It acts directly on the vaccine mRNA itself, modifying it after injection to increase its lifespan, meaning the body unintentionally helps the vaccine last longer than it was originally designed to.

In some cells, the study found that the poly(A) tail of Moderna’s mRNA increased from 100 to as much as 200 nucleotides, meaning the molecule that controls how long the mRNA stays alive and active was doubled in length.

What Does That Mean?

It means the body is induced to generate an enzyme that rewrites the COVID shot after injection, stabilizing it and amplifying spike production beyond what was disclosed in regulatory filings.

Your body could be exposed to more spike protein, for longer, than anyone was told during the shot’s rollout, confirming other studies showing spike stays in the body potentially for more than 700 days.

Not Just Moderna

While Moderna’s vaccine (mRNA-1273) showed the most dramatic re-adenylation, Pfizer’s shot (BNT162b2) also undergoes the same process—just to a lesser degree.

So the problem isn’t limited to one manufacturer.

“The extent of re-adenylation varies: the BioNTech–Pfizer BNT162b2 vaccine shows less potent re-adenylation than mRNA-1273,” the study states, attributing this to Pfizer’s mRNA being less associated with the cell’s endoplasmic reticulum, meaning Pfizer’s mRNA spends less time near the cell’s protein-making machinery, so it doesn’t get modified as aggressively.

In other words: Both vaccines trigger this effect, but Moderna’s formulation causes more sustained and aggressive modification of the vaccine mRNA by the body itself, meaning Moderna’s spike production is likely even longer-lasting.
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